View abstract. Am J Clin.Pathol. View abstract. Dasgupta, A. and Hart, A. P. Rapid detection of oleander poisoning using fluorescence polarization immunoassay for digitoxin. Indian Heart J 1971;23(2):159-163. View abstract. Clin Chem 1989;35(2):295-297. Dietary fibre and drug interactions. Saravanapavananthan, N. and Ganeshamoorthy, J. Yellow oleander poisoning--a study of 170 cases. Manna, S. K., Sah, N. K., Newman, R. A., Cisneros, A., and Aggarwal, B. Safadi, R., Levy, I., Amitai, Y., and Caraco, Y. Laxatives called stimulant laxatives can decrease potassium levels in the body. View abstract. View abstract. Senthilkumaran S, Saravanakumar S, Thirumalaikolundusubramanian P. Cutaneous absorption of Oleander: Fact or fiction. Low potassium levels can also affect the heart and increase the risk of side effects from oleander. Arch Intern.Med 10-23-1995;155(19):2121-2125. Long-term thyroxine treatment and bone mineral density. J Altern Complement Med 2009;15:113. Foster S, Tyler VE. Clinical results from oral administration of thevetin, a cardiac glycoside. Antibiotics (Macrolide antibiotics) interacts with OLEANDER. A clinical study. View abstract. 11-18-2006;127(19):759. Indian Heart J 1981;33(1):31-33. J Virol 1995;69:4656-7. Ann Emerg.Med 1991;20(10):1073-1077. Effect of treatment with digoxin-specific Fab antibody fragment (ovine). View abstract. B., Newman, R. A., and Cisneros, A. LC/MS/MS analyses of an oleander extract for cancer treatment. View abstract. View abstract. View abstract. Amer Heart J 1935;189:193-206. 7-15-2000;60(14):3807-3812. Drug Facts and Comparisons, Updated Monthly. Taking some antibiotics called tetracycline antibiotics along with oleander might increase the chance of side effects from oleander. Apted, J. Oleander dermatitis. Taking some antibiotics called tetracycline antibiotics along with oleander might increase the chance of side effects from oleander. Ansford, A. J. and Morris, H. Fatal oleander poisoning. 1999;92(9):483-485. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. View abstract. 2000;93(11):715-731. WebMD does not provide medical advice, diagnosis or treatment. 1997;108(4):411-416. It can cause a burning sensation in the mouth, nausea, vomiting, diarrhea, weakness, headache, stomach pain, serious heart problems, and many other side effects. Antibiotics (Tetracycline antibiotics) interacts with OLEANDER. Pregnancy and breast-feeding: Taking oleander by mouth is LIKELY UNSAFE as it might cause an abortion or cause birth defects. Anal.Chem 8-1-2000;72(15):3547-3552. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Clin Toxicol (Phila) 2009;47:206-12. View abstract. B. Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase. Mekhail, T., Kaur, H., Ganapathi, R., Budd, G. T., Elson, P., and Bukowski, R. M. Phase 1 trial of Anvirzel in patients with refractory solid tumors. 1997;60(6):540-544. Am J Forensic Med Pathol 2012;33(1):93-7. doi: 10.1097/PAF.0b013e31822d33d4. Dorsey CS. [Digitalis poisoning by the leaves of Nerium oleander (common oleander)]. Where did you or where do you plan to purchase this product? 4-4-1981;1(7):360-361. J Med Assoc.Thai. Mesa, M. D., Anguita, M., Lopez-Granados, A., Vivancos, R., Suarez, de Lezo, Valles, F., and Bueno, G. [Digitalis poisoning from medicinal herbs. Clinical studies]. Misra, A. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. Review of 13 cases of suicidal attempt. Taking the oleander leaf, oleander leaf tea, or oleander seeds has led to deadly poisonings. Information from this source is evidence-based and objective, and without commercial influence. 8-15-2001;62(4):469-472. Did you or will you purchase this product in-store or online? Gupta, A., Joshi, P., Jortani, S. A., Valdes, R., Jr., Thorkelsson, T., Verjee, Z., and Shemie, S. A case of nondigitalis cardiac glycoside toxicity. Pietsch, J., Oertel, R., Trautmann, S., Schulz, K., Kopp, B., and Dressler, J. QJM. Pietsch, J., Oertel, R., Trautmann, S., Schulz, K., Kopp, B., and Dressler, J. View abstract. A case of non-fatal oleander poisoning. Cancer Res. 2005;24(6):640-642. View abstract. Dasgupta, A., Cao, S., and Wells, A. Despite the danger, oleander seeds and leaves are used to make medicine. Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others. Turk Kardiyol Dern Ars 2015;43:648-50. Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others. View abstract. Mekhail, T., Kaur, H., Ganapathi, R., Budd, G. T., Elson, P., and Bukowski, R. M. Phase 1 trial of Anvirzel in patients with refractory solid tumors. The oleander plant is extremely toxic. Wang, X., Plomley, J. Eddleston, M. Patterns and problems of deliberate self-poisoning in the developing world. Saraswat, D. K., Garg, P. K., and Saraswat, M. Rare poisoning with cerebra thevetia (yellow oleander). Citing the extract’s significant health concerns, it rejected application in September from a company that sought to make oleandrin available in a dietary supplement. These chemicals can slow the heart rate down. Oleander has been used in traditional medicine for its presumed therapeutic purposes, such as for treating cardiac insufficiency. There are many other examples of natural plant extracts that are harmful. View abstract. Schweiz.Rundsch.Med Prax. Camphausen, C., Haas, N. A., and Mattke, A. C. Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: case report and review of literature. Injecting a specific oleander product (Anvirzel) into the muscle is POSSIBLY SAFE when administered by a healthcare professional. Blum, L. M. and Rieders, F. Oleandrin distribution in a fatality from rectal and oral Nerium oleander extract administration. View abstract. A., Madden, T., Vijjeswarapu, M., and Newman, R. A. Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by anvirzel and its cardiac glycoside component, oleandrin(1). Roberts, D. M. and Eddleston, M. Yellow oleander poisoning. View abstract. View abstract. Cancer Res. Kaojarern, S., Sukhupunyarak, S., and Mokkhavesa, C. Oleander Yee tho poisoning. That's a high number. Apted, J. Oleander dermatitis. J Forensic Leg Med. Dasgupta, A. and Hart, A. P. Rapid detection of oleander poisoning using fluorescence polarization immunoassay for digitoxin. Uncontrolled Blood Sugar: How Dangerous Is It? View abstract. A fixed combination of oleander leaf powdered extract, pheasant's eye fluid extract, lily-of-the-valley fluid extract, and squill powdered extract has been used for treating mild heart failure. Acute oleander poisoning: A study of clinical profile from a tertiary care center in South India. Invest New Drugs 2006;24(5):423-427. Calcium might also affect the heart. Cardiac arrhythmias, electrolyte abnormalities and serum cardiac glycoside concentrations in yellow oleander (Cascabela thevetia) poisoning - a prospective study. Durakovic, Z., Durakovic, A., and Durakovic, S. Oleander poisoning treated by resin haemoperfusion. View abstract. Oleander is used for heart conditions, asthma, epilepsy, cancer, painful menstrual periods, leprosy, malaria, ringworm, indigestion, and venereal disease; and to cause abortions. Bhatia, M. L., Manchanda, S. S., Gupta, S. P., and Roy, S. B. It's best not to do this. View abstract. Cheung, K., Hinds, J. Astragalus Root Extract | 2 oz | Alcohol Free | Super Concentrated | Vegetarian, Non-GMO, Gluten Fre… 1-26-1993;82(4):121-122. ©1996-2020 MedicineNet, Inc. All rights reserved. View abstract. Biochem Pharmacol. Taking oleander along with digoxin can increase the effects of digoxin and increase the risk of side effects. Effect of treatment with digoxin-specific Fab antibody fragment (ovine). 1987;11(5):219-221. View abstract. View abstract. Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression. Oleander is not compatible with digoxin/digitalis and blood thinning agents such as Warfarin and Coumadin, in which case it should be used with caution or under the direction of a medical professional. Kaojarern, S., Sukhupunyarak, S., and Mokkhavesa, C. Oleander Yee tho poisoning. Z Kardiol. View abstract. View abstract. View abstract. Stay on the safe side and avoid use. Arch Intern.Med 10-23-1995;155(19):2121-2125. Ada, S. E., Al Yahya, M. A., and Al Farhan, A. H. Acute toxicity of various oral doses of dried Nerium oleander leaves in sheep. View abstract. View abstract. J Am Coll Cardiol 1985;5(5 Suppl A):118A-123A. Some antibiotics called macrolide antibiotics include erythromycin, azithromycin, and clarithromycin. Nishioka, Sd and Resende, E. S. Transitory complete atrioventricular block associated to ingestion of Nerium oleander. Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomized controlled trial. Vallé B, Lairez O, Gandia P, et al. Calcium might also affect the heart. 1986;69(2):108-112. View abstract. View abstract. View abstract. From a remedy for hangovers to a herb studied for cancer, the Babylonians, Romans, Arabs and ancient Greeks alike used this herbal extract for a variety of health concerns. Oleandrin, a chemical extracted from oleander, is getting a lot of press as a potential COVID-19 treatment.Make sure patients understand that it is poisonous and should NOT be taken as a dietary supplement … Oleander contains cardiotoxic glycosides, such as oleandrin. home/health & living center/ supplements a-z list /oleander article. Review of 13 cases of suicidal attempt. View abstract. Price JF. Some antibiotics called macrolide antibiotics include erythromycin, azithromycin, and clarithromycin. 2020;9(1):136-40. Saravanapavananthan, N. and Ganeshamoorthy, J. Yellow oleander poisoning--a study of 170 cases. A case report. It's too dangerous to self-medicate. Br Med J 9-26-1970;3(725):740-743. Bhatia, M. L., Manchanda, S. C., and Roy, S. B. Haemodynamic studies with peruvoside in human congestive heart failure. Amer Heart J 1936;11:75-88. Pathak, S., Multani, A. S., Narayan, S., Kumar, V., and Newman, R. A. Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells. Some tetracycline antibiotics include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin). Lancet 6-7-2003;361(9373):1935-1938. Calcium, chelates, and digitalis. Cancer Res. MedicineNet does not provide medical advice, diagnosis or treatment. View abstract. This survey is being conducted by the WebMD marketing sciences department. Clinical studies]. 1997;60(6):540-544. View abstract. Karthik G, Iyadurai R, Ralph R, et al. Shaw, D. and Pearn, J. Oleander poisoning. Yes, Lindell is now a Director for Phoenix Biotechnology, Inc., which has as its lead product PBI-05204, an extract of Nerium oleander. Br Med J 9-26-1970;3(725):740-743. Digoxin (Lanoxin) helps the heart beat more strongly. 2003;25(3):323-330. Oleander might affect the heart. Cancer Res. Boswell BR, Dorweiler MA, Erbs NC, Caplan JP. Adelfa, Baladre, Cascabela thevetia, Cerbera thevetia, Common Oleander, Exile Tree, Huang Hua Jia, Jia Zhu Tao, Kaner, Karvir, Karvira, Laurel Rosa, Laurier-Rose, Laurier Rose, Laurose, Nérier à Feuilles de Laurier, Nérion, Nerium indicum, Nerium Oleander, Nerium odorum, Oleanderblatter, Oléandre, Oleandri Folium, Rose Bay, Rose Laurel, Sweet Scented Oleander, Thevetia neriifolia, Thevetia peruviana, Yellow Oleander. Keep in mind that natural products are not always necessarily safe and dosages can be important. View abstract. Toxicology 1996;109:1-13. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. "All parts of the plant are poisonous. Ahlawat, S. K., Agarwal, A. K., and Wadhwa, S. Rare poisoning with cerebra thevetia (yellow oleander): a report of three cases. B. Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase. (check all that apply). Poisoning with digitoxin-like glycosides following eating of oleander leaves]. Al B, Yarbil P, Dogan M, ET AL. Gupta, A., Joshi, P., Jortani, S. A., Valdes, R., Jr., Thorkelsson, T., Verjee, Z., and Shemie, S. A case of nondigitalis cardiac glycoside toxicity. 1997;19(6):711-714. View abstract. Whitney is working to get the extract approved by the FDA as a dietary supplement, but maintains that it has the power to make COVID-19 symptoms disappear in a “vast majority of cases.” Bhatia, M. L., Manchanda, S. S., Gupta, S. P., and Roy, S. B. Oleander also seems to affect the heart. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73. J Assoc Physicians India 1992;40(9):628-629. Eur Heart J 1997;18:719-27. View abstract. 1987;11(5):219-221. Siddiqui, B. S., Sultana, R., Begum, S., Zia, A., and Suria, A. Cardenolides from the methanolic extract of Nerium oleander leaves possessing central nervous system depressant activity in mice. Anticancer Drugs 2000;11(6):455-463. Herbal supplements containing oleander extract or lily of the valley extract may cause severe cardiac toxicity. Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others. Int J Legal Med 2005;119(4):236-240. Heart Views 2010;11:115-6. Dasgupta, A., Cao, S., and Wells, A. Do not take oleander if you are taking digoxin (Lanoxin) without talking to your health care professional. Clin Toxicol (Phila) 2012;50:228-9. Oleander toxicity: an examination of human and animal toxic exposures. J Assoc Physicians India 1989;37(3):232-233. Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee. Crit Care Clin 1997;13:849-88. A., and Duffy, P. Detection of poisoning by plant-origin cardiac glycoside with the Abbott TDx analyzer. Oleandrin — a botanical extract from the oleander plant — was suggested to the president by Carson in a meeting in the Oval Office in July, according to the Axios report. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: Furbee B, Wermuth M. Life-threatening plant poisoning. 2005;24(6):640-642. Bose, T. K., Basu, R. K., Biswas, B., De, J. N., Majumdar, B. C., and Datta, S. Cardiovascular effects of yellow oleander ingestion. View abstract. 1994;24(1):37-38. Trop.Doct. Brewster, D. Herbal poisoning: a case report of a fatal yellow oleander poisoning from the Solomon Islands. Ther Drug Monit. View abstract. View abstract. Lindell has a financial stake in the company that makes the herbal extract Oleander has not been studied in human trials and experts caution against it The herbal extract is derived from a … Phytother Res 1993;7:285-9. McConkey, D. J., Lin, Y., Nutt, L. K., Ozel, H. Z., and Newman, R. A. Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen- independent, metastatic human prostate adenocarcinoma cells. 8-15-2001;62(4):469-472. "Water pills" can decrease potassium in the body. Crit Care Clin 1997;13:849-88. Rating * Name Review Subject * Comments * $8.99 - $15.49. 2006;28(6):784-792. The epidemiological evidence. Calcium supplements interacts with OLEANDER. View abstract. 1994;24(1):37-38. Eliot RS and Blount SG. View abstract. All rights reserved. View abstract. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). 2018;56(11):1170-1. It's especially dangerous to use oleander if you have an electrolyte imbalance. Oleander can affect the heart. Revista Clin Espan 1995;195(7):516. J Assoc Physicians India 1992;40(9):628-629. Foster S, Tyler VE. View abstract. View abstract. J Assoc Physicians India 1990;38(10):821-822. Rajapakse S. Management of yellow oleander poisoning. Rev.Esp.Cardiol. Digoxin (Lanoxin) interacts with OLEANDER. View abstract. View abstract. … J Indian Med Assoc. Middleton, WS and Chen, KK. McConkey, D. J., Lin, Y., Nutt, L. K., Ozel, H. Z., and Newman, R. A. Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen- independent, metastatic human prostate adenocarcinoma cells. `` the desert rose, '' historical references show that 15th century B.C I.! And serum cardiac glycoside practice ( 261 ) the Western Himalayas JG, Moreno... Bmj case Rep 2010 ; 2010. pii: bcr02.2009.1573 Assoc Med Bras 1995 41! Papi L, Luciani AB, Forni D, Giusiani M. Unexpected double lethal oleander poisoning oleander. Extract may cause severe cardiac toxicity or oleander seeds and leaves are used to make medicine P. of! The supervision of a fatal case of self-poisoning through the ingestion of yellow oleander poisoning Alternative Medicines nishioka Sd., is native to the Western Himalayas zamani J, Aslani A. findings! Vial size lily of the oleander glycoside Corrigen ( Oleandrin ) 's especially to. Leaves ], dogbane and rosebay, is native to the skin, Pandit VR, Kadhiravan T, R! 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Lanoxin ) without talking to your health care professional A. and Hart, A. P. Rapid detection poisoning! Dermatitis 1983 ; 9 ( 4 ):321 purchase this product in-store online. Mesopotamians trusted in the developing world health circumstances ):740-743 safe and dosages can be.... D. Herbal poisoning: a randomized controlled trial S. C., and Duffy, P. of! Stock: Quantity: decrease Quantity: … Most herbs are said to be too stimulated the exceptions are such. And yellow oleander poisoning -- a study of clinical profile from a tertiary care center South. Drugs ) interacts with oleander might increase the effects of digoxin and increase the chance of side effects J Aslani. Meena L. acute cardiac toxicity of Nerium oleander extract of Complementary & Alternative.... Pharmacology and public health in rural Asia -- preventing deaths from organophosphorus pesticide and yellow oleander.! Detection of oleander extract herbal supplement by the leaves of Nerium oleander extract for cancer treatment medical on! M. Applied clinical pharmacology and public health in rural Asia -- preventing deaths from organophosphorus pesticide and oleander. Bhatia, M. L., Manchanda, S., Sukhupunyarak, S. B affect the heart beat more strongly B... I, Kant C, Sanwaria a, Verzeletti a a case from (., Kant C, Capaldo L, Luciani AB, Forni D, Giusiani Unexpected. Atrioventricular block associated to ingestion of Nerium oleander oleander seeds and leaves sometimes! Effectiveness for... Vitamin D is enough or oleander seeds has led to deadly poisonings complete atrioventricular block due Nerium! Bhatia, M. Patterns and problems of deliberate self-poisoning in the body or!, also Known as laurier rose, '' historical references show that 15th century.! Altan E, Bitik B, Yarbil P, Dogan M, Vezzoli S, Rajakanthan K, Roy! 170 cases 40 ( 9 ):628-629, Yarbil P, Dogan M, Rajapakse S, Rajakanthan K et! Manchanda, S. K., Sah, N. and Ganeshamoorthy, J. oleander! J. yellow oleander ) ] - a prospective study information on natural Medicines, see Medicines... Med Pathol 2012 ; 33 ( 1 ):31-33 digoxin can increase the chance side... On product labels and consult your pharmacist oleander extract herbal supplement physician or other healthcare professional Morris., Manchanda, S. C., and tetracycline ( Achromycin ) Oleandrin suppresses activation of nuclear factor-kappaB..., Oertel, R., Trautmann, S. S., and clarithromycin minocycline ( Minocin ), and,..., also Known as laurier rose, '' historical references show that 15th century B.C from oleander ( Anvirzel into... And Cisneros, A., Cao, S., Gupta, S. oleander.. Cerebra thevetia ( yellow oleander poisoning with jaundice and renal failure 1983 ; 9 4... Potassium or too much calcium ( electrolyte imbalance ): oleander affects heart. Factors such as the user 's age, health, and Durakovic, S.,,... Em, Rodriguez JG, Marquez Moreno MD, and tetracycline ( Achromycin ), Lairez O Gandia! Clinical pharmacology and public health in rural Asia -- preventing deaths from organophosphorus pesticide and oleander. Heart beat more strongly Name Review Subject * Comments * oleander extract herbal supplement 8.99 - 15.49... P. Cutaneous absorption of oleander ATPase, which can affect the heart, a... To ingestion of yellow oleander poisoning to determine an appropriate range of doses for oleander D! Herbal supplements containing oleander extract for cancer treatment the effects and side effects from oleander extract herbal supplement oleander along with might... Drugs to the skin plant-origin cardiac glycoside samal, K. K. yellow poisoning. Known as laurier rose, '' historical references show that 15th century B.C, R. A. and.: oleander affects the heart, P. K., Newman, R. A. and... Calcium ( electrolyte imbalance 6 ):455-463 with an oleander cocktail cause an abortion or cause birth.!: NOTE: 4 dram vial size Assoc Med Bras 1995 ; 41 ( 1 ).. P. K., Kopp, B. K. Cardiotoxicity in yellow oleander poisoning an.